Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.44 |
| ▸ | ITK | Q08881 | 12/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033870 | 1.00 | BTK (0.44) | BTKITKKLKB1MAP4K1PRMT5 | |
| SCHEMBL29958524 | 0.87 | BTK (0.44) | BTKITKKLKB1MAP4K1PRMT5 | |
| SCHEMBL27033831 | 0.87 | BTK (0.44) | BTKITKKLKB1MAP4K1PRMT5 | |
| SCHEMBL29202566 | 0.82 | BTK (0.41) | BTKITKKLKB1MAP4K1PRMT5 | |
| SCHEMBL29481417 | 0.80 | PRMT5 (0.48) | BTKITKKLKB1MAP4K1PRMT5 | |
| SCHEMBL7443703 | 0.80 | PRMT5 (0.48) | BTKITKKLKB1MAP4K1PRMT5 | |
| SCHEMBL29958074 | 0.79 | BTK (0.39) | BTKITKKLKB1MAP4K1F2 | |
| SCHEMBL27033795 | 0.79 | BTK (0.39) | BTKITKKLKB1MAP4K1F2 | |
| Hydrochloric Acid SCHEMBL7213801 | 0.78 | PRMT5 (0.47) | BTKITKKLKB1MAP4K1PRMT5 | |
| Hydrochloric Acid SCHEMBL16881193 | 0.78 | PRMT5 (0.47) | BTKITKKLKB1MAP4K1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |