Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 11/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 6/20 | 0.39 |
| ▸ | RAF1 | P04049 | 5/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033957 | 1.00 | KLKB1 (0.40) | KLKB1ACVRL1BRAFRAF1METTL3 | |
| SCHEMBL24737728 | 0.86 | ACVRL1 (0.48) | KLKB1ACVRL1BRAFMETTL3JAK2 | |
| SCHEMBL29879447 | 0.82 | KLKB1 (0.38) | KLKB1METTL3 | |
| SCHEMBL29302927 | 0.82 | KLKB1 (0.38) | KLKB1METTL3 | |
| SCHEMBL27033947 | 0.81 | PIK3C3 (0.39) | KLKB1ACVRL1BRAFMETTL3TYK2 | |
| SCHEMBL27033738 | 0.80 | KLKB1 (0.43) | KLKB1BRAFMETTL3 | |
| SCHEMBL29879527 | 0.80 | KLKB1 (0.41) | KLKB1ACVRL1METTL3TYK2 | |
| SCHEMBL29137049 | 0.80 | KLKB1 (0.41) | KLKB1ACVRL1METTL3TYK2 | |
| SCHEMBL29879879 | 0.80 | KLKB1 (0.41) | KLKB1ACVRL1METTL3TYK2 | |
| SCHEMBL24737729 | 0.80 | KLKB1 (0.41) | KLKB1ACVRL1METTL3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |