Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033973 | 1.00 | CYP2C9 (0.37) | CYP2C9CXCL8CHRM1HSD11B1AGTR1 | |
| SCHEMBL30711691 | 0.92 | SUCNR1 (0.36) | CYP2C9CXCL8CHRM1AGTR1AGTR2 | |
| SCHEMBL29174269 | 0.92 | SUCNR1 (0.36) | CYP2C9CXCL8CHRM1AGTR1AGTR2 | |
| SCHEMBL27033350 | 0.91 | AGTR1 (0.35) | CYP2C9HSD11B1AGTR1AGTR2SHMT1 | |
| SCHEMBL30711683 | 0.91 | AGTR1 (0.35) | CYP2C9HSD11B1AGTR1AGTR2SHMT1 | |
| SCHEMBL27033759 | 0.88 | MAPT (0.36) | HSD11B1AGTR1AGTR2KDM4ESHMT1 | |
| SCHEMBL1197446 | 0.85 | AGTR1 (0.36) | CYP2C9HSD11B1AGTR1AGTR2KDM4E | |
| SCHEMBL27724819 | 0.83 | AGTR1 (0.37) | CYP2C9HSD11B1AGTR1AGTR2KDM4E | |
| SCHEMBL29174287 | 0.81 | MEN1 (0.33) | AGTR1AGTR2KDM4ESHMT1ALDH1A1 | |
| SCHEMBL29174268 | 0.81 | KLK7 (0.34) | CYP2C9AGTR1AGTR2SHMT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |