Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 15/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FSHR | P23945 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033715 | 1.00 | KLKB1 (0.41) | KLKB1METTL3CSNK1DDGAT1EGFR | |
| SCHEMBL24729616 | 0.88 | MAPK1 (0.45) | KLKB1METTL3DGAT1 | |
| SCHEMBL29957969 | 0.87 | KLKB1 (0.40) | KLKB1METTL3DGAT1 | |
| SCHEMBL27033470 | 0.87 | KLKB1 (0.40) | KLKB1METTL3DGAT1 | |
| SCHEMBL29927020 | 0.86 | KLKB1 (0.40) | KLKB1METTL3DGAT1TSHRFSHR | |
| SCHEMBL24729482 | 0.86 | KLKB1 (0.40) | KLKB1METTL3DGAT1TSHRFSHR | |
| SCHEMBL24729565 | 0.85 | KLKB1 (0.41) | KLKB1METTL3DGAT1 | |
| SCHEMBL24729595 | 0.83 | KLKB1 (0.41) | KLKB1METTL3DGAT1 | |
| SCHEMBL29927164 | 0.83 | KLKB1 (0.41) | KLKB1METTL3DGAT1 | |
| SCHEMBL29136881 | 0.82 | KLKB1 (0.42) | KLKB1METTL3DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240382482-A1 | PLASMA KALLIKREIN INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2024-11-21 | — | — | US | disclosed |
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240382482-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK5, KLK1 | KLKB1 1/4885METTL3 4613/4885CSNK1D 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.