Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 14/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | FSHR | P23945 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29927020 | 1.00 | KLKB1 (0.40) | KLKB1METTL3DGAT1TSHRFSHR | |
| SCHEMBL24729564 | 0.89 | RAB9A (0.40) | KLKB1METTL3TSHR | |
| SCHEMBL29927651 | 0.89 | RAB9A (0.40) | KLKB1METTL3TSHR | |
| SCHEMBL24729469 | 0.89 | KLKB1 (0.40) | KLKB1METTL3DGAT1TSHRFSHR | |
| SCHEMBL24729618 | 0.88 | KLKB1 (0.41) | KLKB1METTL3 | |
| SCHEMBL24729616 | 0.87 | MAPK1 (0.45) | KLKB1METTL3DGAT1 | |
| SCHEMBL29958693 | 0.86 | KLKB1 (0.41) | KLKB1METTL3DGAT1TSHRFSHR | |
| SCHEMBL27033715 | 0.86 | KLKB1 (0.41) | KLKB1METTL3DGAT1TSHRFSHR | |
| SCHEMBL24729663 | 0.86 | KLKB1 (0.39) | KLKB1METTL3DGAT1 | |
| SCHEMBL24729588 | 0.86 | KLKB1 (0.40) | KLKB1METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |