Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402135 | 1.00 | NR1H2 (0.52) | NR1H2HRH4EPHX2PIK3CAMTOR | |
| SCHEMBL6822196 | 0.87 | KDM4E (0.46) | LMNAALOX15TSHRMEN1KMT2A | |
| SCHEMBL10155940 | 0.86 | HPGD (0.48) | LMNATSHRMEN1KMT2A | |
| SCHEMBL31316989 | 0.85 | PIK3CA (0.51) | NR1H2HRH4PIK3CAMTORLMNA | |
| SCHEMBL16047564 | 0.85 | PIK3CA (0.51) | NR1H2HRH4PIK3CAMTORLMNA | |
| SCHEMBL3926057 | 0.84 | HTT (0.52) | TP53TSHR | |
| SCHEMBL4287349 | 0.83 | EPHX2 (0.48) | EPHX2TSHRHSP90AA1 | |
| SCHEMBL15286036 | 0.83 | HRH4 (0.49) | HRH4EPHX2PIK3CAMTORLMNA | |
| SCHEMBL24566019 | 0.82 | CRBN (0.42) | NR1H2TSHRSCD | |
| SCHEMBL20682533 | 0.82 | ALOX15 (0.57) | HRH4EPHX2PIK3CAMTORLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226182-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-27 | — | — | WO | disclosed |