Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.47 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | PRKCI | P41743 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692680 | 1.00 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL21620550 | 0.85 | LRRK2 (0.49) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL855137 | 0.82 | HTR2A (0.48) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL16785960 | 0.82 | LRRK2 (0.62) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL23883560 | 0.78 | LRRK2 (0.59) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL19932612 | 0.77 | CCNK (0.44) | LRRK2ROCK2ROCK1CDC42BPAAXL | |
| SCHEMBL1045493 | 0.77 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL2237935 | 0.77 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL23169939 | 0.77 | TRPA1 (0.46) | LRRK2CDK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL19478522 | 0.77 | CCNK (0.44) | LRRK2CDK2CDK9CDK5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341124-B | Protein tyrosine phosphatase inhibitors | ARRAY生物制药公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-118530260-A | Fused bicyclic derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-118530261-A | Fused bicyclic derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-115397815-B | Fused bicyclic derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| US-20230148417-A1 | FUSED BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| EP-4122922-A1 | FUSED BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-01-25 | — | — | EP | disclosed |
| CN-115397815-A | Condensed bicyclic derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| WO-2022226182-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230148417-A1 | FUSED BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | WEE2, AKT1S1, WEE1 | LRRK2 458/4885CDK2 76/4885CDK9 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.