Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.54 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916911 | 0.87 | KMT2A (0.65) | GAAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3664093 | 0.85 | TSHR (0.55) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| SCHEMBL14597968 | 0.81 | HDAC1 (0.67) | MEN1KMT2AHDAC1HDAC7MAPK1 | |
| SCHEMBL10766110 | 0.81 | SMN1; SMN2 (0.64) | GAAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6318770 | 0.77 | HDAC1 (0.58) | ALDH1A1MEN1KMT2AHDAC1HDAC7 | |
| SCHEMBL10988558 | 0.77 | ESR1 (0.74) | GAAALDH1A1SMN1; SMN2TSHRLMNA | |
| SCHEMBL37476 | 0.77 | ESR1 (0.85) | GAAALDH1A1SMN1; SMN2TSHRLMNA | |
| SCHEMBL8084590 | 0.76 | TSHR (0.64) | ALDH1A1SMN1; SMN2TSHRLMNACYP1A2 | |
| SCHEMBL28816311 | 0.76 | SMN1; SMN2 (0.66) | GAAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12905303 | 0.76 | HDAC1 (0.68) | ALDH1A1MEN1KMT2AHDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |