Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23409854 | 1.00 | TGFBR1 (0.56) | TGFBR1MAPK14CNR1ENPP2KDM4E | |
| SCHEMBL28822069 | 0.91 | TGFBR1 (0.56) | TGFBR1MAPK14ALDH1A1LMNAAURKA | |
| SCHEMBL29959800 | 0.89 | TGFBR1 (0.58) | TGFBR1MAPK14CNR1RAB9AHPGD | |
| SCHEMBL23409679 | 0.89 | TGFBR1 (0.58) | TGFBR1MAPK14CNR1RAB9AHPGD | |
| SCHEMBL23409669 | 0.89 | TGFBR1 (0.56) | TGFBR1MAPK14AURKAAURKBMAPT | |
| SCHEMBL29959791 | 0.89 | TGFBR1 (0.56) | TGFBR1MAPK14AURKAAURKBMAPT | |
| SCHEMBL23409675 | 0.89 | TGFBR1 (0.67) | TGFBR1MAPK14KDM4ERAB9A | |
| SCHEMBL29959983 | 0.89 | TGFBR1 (0.67) | TGFBR1MAPK14KDM4ERAB9A | |
| SCHEMBL28822077 | 0.88 | TGFBR1 (0.59) | TGFBR1MAPK14CNR1ENPP2LMNA | |
| SCHEMBL28822071 | 0.88 | TGFBR1 (0.69) | TGFBR1MAPK14CNR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |