Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380662 | 1.00 | KDM1A (0.48) | KDM1ANOTUMHDAC1HDAC6LMNA | |
| SCHEMBL641007 | 0.93 | LMNA (0.51) | KDM1ANOTUMHDAC1HDAC6LMNA | |
| SCHEMBL29457581 | 0.93 | LMNA (0.51) | KDM1ANOTUMHDAC1HDAC6LMNA | |
| SCHEMBL7004709 | 0.84 | NOTUM (0.64) | KDM1ANOTUMHDAC1HDAC6LMNA | |
| SCHEMBL30667212 | 0.84 | NOTUM (0.64) | KDM1ANOTUMHDAC1HDAC6LMNA | |
| SCHEMBL16359586 | 0.83 | KDM1A (0.48) | KDM1ANOTUMHDAC1HDAC6LMNA | |
| SCHEMBL3127747 | 0.83 | NOTUM (0.63) | NOTUMHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL29476005 | 0.83 | NOTUM (0.63) | NOTUMHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL6341898 | 0.82 | BRD4 (0.46) | KDM1ABRD4PDK4UCHL1BUB1 | |
| SCHEMBL3531672 | 0.82 | MEN1 (0.43) | KDM1ANOTUMHDAC1HDAC6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118791498-A | Tetracyclic compound, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2024-10-18 | — | — | CN | disclosed |
| WO-2022204150-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CNS DISORDERS | BLUE OAK PHARMACEUTICALS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |