Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299623 | 0.86 | KDM4E (0.52) | KDM4ERAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL290134 | 0.79 | KDM4E (0.75) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289866 | 0.78 | SMN1; SMN2 (0.59) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289411 | 0.77 | KDM4E (0.53) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289596 | 0.77 | SMN1; SMN2 (0.74) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289408 | 0.76 | SMN1; SMN2 (0.72) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL290214 | 0.75 | KDM4E (0.54) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289635 | 0.75 | KDM4E (0.57) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL3748204 | 0.74 | HDAC6 (0.60) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289880 | 0.74 | SMN1; SMN2 (0.54) | KDM4ERAB9AGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |