Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087739 | 0.77 | RPS6KA3 (0.52) | NAMPTMAPKAPK2 | |
| SCHEMBL2996302 | 0.75 | MAPKAPK2 (0.75) | NAMPTMAPKAPK2MAPK1MAP2K1 | |
| Phosphoric Acid SCHEMBL6965225 | 0.69 | MAPKAPK2 (0.56) | MAPKAPK2MAPK1MAP2K1NPC1RAB9A | |
| Phosphoric Acid SCHEMBL6965241 | 0.68 | MAPKAPK2 (0.53) | MAPKAPK2MAPK1MAP2K1NPC1RAB9A | |
| SCHEMBL3001121 | 0.68 | MAPKAPK2 (0.61) | NAMPTMAPKAPK2MAPK1MAP2K1NPC1 | |
| SCHEMBL2999010 | 0.68 | MAPKAPK2 (1.00) | NAMPTMAPKAPK2MAPK1MAP2K1 | |
| SCHEMBL8591674 | 0.68 | MAPKAPK2 (0.55) | NAMPTMAPKAPK2MAPK1MAP2K1NPC1 | |
| SCHEMBL2998184 | 0.68 | MAPKAPK2 (1.00) | MAPKAPK2MAPK1MAP2K1LMNAALDH1A1 | |
| SCHEMBL2998498 | 0.68 | MAPKAPK2 (0.75) | NAMPTMAPKAPK2MAPK1MAP2K1NPC1 | |
| SCHEMBL2990814 | 0.68 | MAPKAPK2 (0.60) | NAMPTMAPKAPK2MAPK1MAP2K1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | NAMPT 597/4885MAPKAPK2 1/4885MAPK1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.