Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 14/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | RPS6KA2 | Q15349 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2996306 | 0.77 | NAMPT (0.52) | MAPKAPK2NAMPT | |
| SCHEMBL3087732 | 0.74 | RPS6KA3 (0.72) | RPS6KA3MAPKAPK2RPS6KA2 | |
| SCHEMBL12598195 | 0.69 | RPS6KA3 (1.00) | RPS6KA3MAPKAPK2RPS6KA2 | |
| SCHEMBL12598243 | 0.66 | RPS6KA3 (1.00) | RPS6KA3MAPKAPK2RPS6KA2 | |
| SCHEMBL3086102 | 0.65 | RPS6KA3 (1.00) | RPS6KA3MAPKAPK2RPS6KA2 | |
| SCHEMBL13143255 | 0.65 | RPS6KA3 (1.00) | RPS6KA3MAPKAPK2RPS6KA2 | |
| SCHEMBL349933 | 0.65 | NAMPT (0.80) | NAMPT | |
| SCHEMBL29457342 | 0.65 | NAMPT (0.80) | NAMPT | |
| SCHEMBL782771 | 0.65 | GPR119 (0.50) | NAMPT | |
| SCHEMBL14892574 | 0.65 | RPS6KA3 (1.00) | RPS6KA3MAPKAPK2RPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790712-B2 | Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICAL, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20060276453-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276453-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | RPS6KA3 302/4885MAPKAPK2 1/4885NAMPT 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.