Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18668699 | 1.00 | SMN1; SMN2 (0.36) | SMN1; SMN2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22856279 | 0.78 | JAK1 (0.41) | SMN1; SMN2 | |
| SCHEMBL24276487 | 0.78 | JAK1 (0.41) | SMN1; SMN2 | |
| SCHEMBL18668653 | 0.78 | JAK1 (0.41) | SMN1; SMN2 | |
| SCHEMBL21797556 | 0.77 | CHRNB2 (0.31) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7 | |
| SCHEMBL30638252 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL18505842 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL14801201 | 0.77 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7 | |
| SCHEMBL14801203 | 0.77 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7 | |
| SCHEMBL29963536 | 0.77 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115124538-A | Bicyclic compounds as ATX inhibitors | 豪夫迈·罗氏有限公司 | 2022-09-30 | — | — | CN | disclosed |