Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CCRL2 | O00421 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24750365 | 1.00 | CCR2 (0.38) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750376 | 1.00 | CCR2 (0.38) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750380 | 0.91 | TDP1 (0.38) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750206 | 0.91 | TDP1 (0.38) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750371 | 0.91 | TDP1 (0.38) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750374 | 0.91 | TDP1 (0.38) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750202 | 0.91 | TDP1 (0.38) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750381 | 0.91 | CCR2 (0.39) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL29965690 | 0.91 | CCR2 (0.39) | CCR2KCNH2TDP1LMNACCRL2 | |
| SCHEMBL24750382 | 0.90 | EPHX2 (0.37) | CCR2KCNH2LMNAKMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313988-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204481-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2022-09-29 | — | — | WO | disclosed |