Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.64 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.64 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21470183 | 1.00 | DHODH (0.64) | DHODHTRPM8TRPA1TAS2R14MAPK1 | |
| SCHEMBL8048868 | 0.82 | TRPM8 (0.76) | DHODHTRPM8TRPA1TAS2R14TRPM2 | |
| SCHEMBL8048873 | 0.82 | TRPM8 (0.76) | DHODHTRPM8TRPA1TAS2R14TRPM2 | |
| SCHEMBL29966740 | 0.82 | TRPM8 (0.76) | DHODHTRPM8TRPA1TAS2R14TRPM2 | |
| Lithium SCHEMBL8048874 | 0.81 | TRPM8 (0.74) | DHODHTRPM8TRPA1TAS2R14TRPM2 | |
| SCHEMBL8058714 | 0.81 | TRPM8 (0.74) | DHODHTRPM8TRPA1TAS2R14ALDH1A1 | |
| SCHEMBL8060378 | 0.81 | TRPM8 (0.74) | DHODHTRPM8TRPA1TAS2R14TRPM2 | |
| SCHEMBL8060371 | 0.81 | TRPM8 (0.74) | DHODHTRPM8TRPA1TAS2R14TRPM2 | |
| SCHEMBL8065731 | 0.79 | DHODH (1.00) | DHODHTRPM8TRPA1NPC1RAB9A | |
| SCHEMBL8065734 | 0.79 | DHODH (1.00) | DHODHTRPM8TRPA1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110357789-B | N-substituted acrylamide derivative as DHODH inhibitor and preparation and application thereof | 华东理工大学 | 2022-09-30 | — | — | CN | disclosed |