SCHEMBL29966686

SCHEMBL29966686

Cc1ncc([C@@H]2CCON2C(=O)C(C)(C)C(F)F)cc1F

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 16/20 0.39
ABL1 P00519 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20580384 1.00 RIPK1 (0.39) RIPK1ABL1
SCHEMBL22210897 1.00 RIPK1 (0.39) RIPK1ABL1
SCHEMBL18921502 0.89 RIPK1 (0.39) RIPK1ABL1
SCHEMBL18921477 0.85 RIPK1 (0.44) RIPK1
SCHEMBL18921464 0.85 RIPK1 (0.36) RIPK1
SCHEMBL18921383 0.83 RIPK1 (0.41) RIPK1ABL1
SCHEMBL18921296 0.82 RIPK1 (0.36) RIPK1ABL1
SCHEMBL20580249 0.82 RIPK1 (0.36) RIPK1
SCHEMBL18921349 0.82 RIPK1 (0.36) RIPK1ABL1
SCHEMBL22210862 0.81 RIPK1 (0.39) RIPK1ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108602809-B Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) 戴纳立制药公司 2022-09-30 CN disclosed