Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SPR | P35270 | 3/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18921280 | 1.00 | RIPK1 (0.35) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL18921462 | 1.00 | RIPK1 (0.35) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL18921282 | 1.00 | RIPK1 (0.35) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL20580288 | 0.89 | RIPK1 (0.36) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL22210975 | 0.86 | RIPK1 (0.34) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL20580735 | 0.86 | RIPK1 (0.34) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL20580091 | 0.83 | RIPK1 (0.33) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL22210971 | 0.83 | RIPK1 (0.33) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL22210918 | 0.83 | RIPK1 (0.33) | RIPK1KDM1AMAOAMAOBGRIN1 | |
| SCHEMBL22210959 | 0.83 | RIPK1 (0.38) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602809-B | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2022-09-30 | — | — | CN | disclosed |