SCHEMBL29966955

SCHEMBL29966955

Fc1cc(-c2noc(C(F)(F)Cl)n2)c(F)cc1CBr

nearest known ligand 0.39

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 20/20 0.39
HDAC1 Q13547 19/20 0.39
HDAC5 Q9UQL6 17/20 0.39
HDAC8 Q9BY41 8/20 0.38
HDAC4 P56524 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20528700 0.89 HDAC1 (0.47) HDAC6HDAC1HDAC5HDAC8
Hydrochloric Acid SCHEMBL29975002 0.85 HDAC6 (0.45) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL26968022 0.80 HDAC6 (0.53) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL29966796 0.80 HDAC1 (0.54) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL29966357 0.79 HDAC1 (0.41) HDAC6HDAC1HDAC5HDAC8
SCHEMBL29975221 0.74 HDAC1 (0.43) HDAC6HDAC1HDAC5HDAC8
SCHEMBL20528686 0.72 HDAC1 (0.47) HDAC6HDAC1HDAC5HDAC8
SCHEMBL26968026 0.72 HDAC1 (0.53) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL26968033 0.69 HDAC6 (0.53) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL26968035 0.69 HDAC6 (0.48) HDAC6HDAC1HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022207494-A1 3-(HETERO)ARYL-5-CHLORODIFLUOROMETHYL-1,2,4-OXADIAZOLE AS FUNGICIDE BAYER AKTIENGESELLSCHAFT (DE) 2022-10-06 WO disclosed
WO-2022207496-A1 3-(HETERO)ARYL-5-CHLORODIFLUOROMETHYL-1,2,4-OXADIAZOLE AS FUNGICIDE BAYER AKTIENGESELLSCHAFT (DE) 2022-10-06 WO disclosed