Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 6/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753890 | 1.00 | CYP11B1 (0.43) | CYP11B1CYP11B2NPY5RABL1OPRM1 | |
| SCHEMBL29968501 | 0.87 | ABL1 (0.43) | CYP11B1CYP11B2NPY5RABL1OPRM1 | |
| SCHEMBL23762979 | 0.87 | ABL1 (0.43) | CYP11B1CYP11B2NPY5RABL1OPRM1 | |
| SCHEMBL29968622 | 0.87 | CYP1A2 (0.47) | CYP11B1CYP11B2NPY5RDYRK1ACYP1A2 | |
| SCHEMBL29970429 | 0.87 | CYP1A2 (0.47) | CYP11B1CYP11B2NPY5RDYRK1ACYP1A2 | |
| SCHEMBL23763333 | 0.81 | HDAC1 (0.50) | ABL1OPRM1AHRCYP1A2CYP3A4 | |
| SCHEMBL29968113 | 0.81 | HDAC1 (0.50) | ABL1OPRM1AHRCYP1A2CYP3A4 | |
| SCHEMBL23762999 | 0.80 | PIM1 (0.47) | CYP11B1CYP11B2NPY5RKCNH2 | |
| SCHEMBL23753909 | 0.80 | ABL1 (0.48) | ABL1DYRK1ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29967855 | 0.80 | PIM1 (0.47) | CYP11B1CYP11B2NPY5RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-115151534-B | Inhibitors of interleukin-1 receptor associated kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof and methods of use thereof | 南京药石科技股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | disclosed |