Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 5/20 | 0.69 |
| ▸ | PRKCG | P05129 | 5/20 | 0.69 |
| ▸ | PRKCB | P05771 | 5/20 | 0.69 |
| ▸ | PRKCA | P17252 | 5/20 | 0.69 |
| ▸ | PRKCH | P24723 | 5/20 | 0.69 |
| ▸ | PRKCI | P41743 | 5/20 | 0.69 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.69 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.69 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.69 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.69 |
| ▸ | PRKACA | P17612 | 4/20 | 0.69 |
| ▸ | PRKACG | P22612 | 4/20 | 0.69 |
| ▸ | PRKACB | P22694 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21545920 | 1.00 | PRKD3 (0.69) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL13186232 | 0.85 | PRKCD (0.86) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL13186226 | 0.84 | PRKCD (0.88) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2456849 | 0.84 | PRKCD (0.88) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL30439349 | 0.84 | PRKCD (0.88) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL23795295 | 0.84 | PRKCD (0.88) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL30439885 | 0.84 | PRKCD (0.88) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL4729656 | 0.84 | PRKD3 (0.60) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL7318883 | 0.84 | PRKD3 (0.60) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL23795291 | 0.83 | PRKCD (0.88) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304717-A1 | USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY | Chronic Airway Therapeutics Limited (AU) | 2024-01-17 | — | — | EP | claimed |
| WO-2022192252-A1 | USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY | CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) | 2022-09-15 | — | — | WO | claimed |
| WO-2024189434-A1 | USE OF NADOLOL TO TREAT PULMONARY SYMPTOMS ASSOCIATED WITH INFECTIONS WITH SARS-CoV-2 | CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) | 2024-09-19 | — | — | WO | disclosed |
| EP-4304717-A1 | USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY | Chronic Airway Therapeutics Limited (AU) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192252-A1 | USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY | CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) | 2022-09-15 | — | — | WO | disclosed |