Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 5/20 | 0.60 |
| ▸ | PRKCG | P05129 | 5/20 | 0.60 |
| ▸ | PRKCB | P05771 | 5/20 | 0.60 |
| ▸ | PRKCA | P17252 | 5/20 | 0.60 |
| ▸ | PRKCH | P24723 | 5/20 | 0.60 |
| ▸ | PRKCI | P41743 | 5/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.60 |
| ▸ | PRKACA | P17612 | 4/20 | 0.60 |
| ▸ | PRKACG | P22612 | 4/20 | 0.60 |
| ▸ | PRKACB | P22694 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318883 | 0.89 | PRKD3 (0.60) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL29968321 | 0.84 | PRKD3 (0.69) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL21545920 | 0.84 | PRKD3 (0.69) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2455144 | 0.82 | PRKCD (0.67) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL7318744 | 0.81 | ROCK2 (0.53) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL16712961 | 0.80 | CYP3A4 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL9016173 | 0.79 | PRKD3 (0.73) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL4727206 | 0.79 | ROCK2 (0.66) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL4727733 | 0.78 | PRKD3 (0.61) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL4728844 | 0.78 | ROCK2 (0.62) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| US-4798897-A | (AMINOALKYL)AMINOSULFONYL-SUBSTITUTED CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1989-01-17 | — | — | US | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | PRKD3 3105/4885PRKCG 801/4885PRKCB 1377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.