Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.47 |
| ▸ | CSF1R | P07333 | 6/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.39 |
| ▸ | DLK1 | P80370 | 1/20 | 0.39 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23763193 | 1.00 | MAP3K12 (0.47) | MAP3K12CSF1RKITPDGFRADLK1 | |
| SCHEMBL23763418 | 0.91 | MAP3K12 (0.41) | MAP3K12FGFR3FGFR1FGFR2SYK | |
| SCHEMBL29968218 | 0.91 | MAP3K12 (0.41) | MAP3K12FGFR3FGFR1FGFR2SYK | |
| SCHEMBL29967963 | 0.89 | MAP3K12 (0.50) | MAP3K12CSF1RKITPDGFRADLK1 | |
| SCHEMBL23763158 | 0.89 | MAP3K12 (0.50) | MAP3K12CSF1RKITPDGFRADLK1 | |
| SCHEMBL23763195 | 0.87 | MAP3K12 (0.38) | MAP3K12CSF1RKITPDGFRADYRK1A | |
| SCHEMBL23763209 | 0.83 | ROCK2 (0.38) | MAP3K12CSF1RKITPDGFRADYRK1A | |
| SCHEMBL23763221 | 0.82 | MAP3K12 (0.50) | MAP3K12CSF1RKITPDGFRADLK1 | |
| SCHEMBL23763470 | 0.81 | MAP3K12 (0.53) | MAP3K12CSF1RKITPDGFRADLK1 | |
| SCHEMBL23763205 | 0.81 | MAP3K12 (0.42) | MAP3K12CSF1RKITDLK1DRG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151534-B | Inhibitors of interleukin-1 receptor associated kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof and methods of use thereof | 南京药石科技股份有限公司 | 2024-02-06 | — | — | CN | claimed |
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-115151534-B | Inhibitors of interleukin-1 receptor associated kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof and methods of use thereof | 南京药石科技股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | disclosed |