Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | KIT | P10721 | 4/20 | 0.47 |
| ▸ | FLT1 | P17948 | 4/20 | 0.47 |
| ▸ | FLT4 | P35916 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 3/20 | 0.41 |
| ▸ | BLK | P51451 | 3/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28871229 | 1.00 | KDR (0.52) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL422378 | 0.85 | KDR (0.56) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL29968188 | 0.78 | KDR (0.46) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL28871314 | 0.78 | KDR (0.46) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL28871230 | 0.76 | MAP2K4 (0.44) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL29967811 | 0.76 | MAP2K4 (0.44) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL1384538 | 0.76 | KDR (0.71) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL28871271 | 0.74 | CYP2C9 (0.51) | KDRFLT3NPC1TP53RAB9A | |
| SCHEMBL422432 | 0.73 | KDR (0.82) | KDRFLT3CSF1RKITFLT1 | |
| SCHEMBL424772 | 0.72 | KDR (0.84) | KDRFLT3CSF1RKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-B | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2024-08-06 | — | — | CN | disclosed |
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |