Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | PDE6D | O43924 | 1/20 | 0.56 |
| ▸ | PDE6A | P16499 | 1/20 | 0.56 |
| ▸ | PDE6G | P18545 | 1/20 | 0.56 |
| ▸ | PDE6B | P35913 | 1/20 | 0.56 |
| ▸ | PDE6C | P51160 | 1/20 | 0.56 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31694381 | 1.00 | PDE5A (0.59) | PDE5AALDH1A1PDE6DPDE6APDE6G | |
| SCHEMBL1679801 | 1.00 | PDE5A (0.59) | PDE5AALDH1A1PDE6DPDE6APDE6G | |
| SCHEMBL16816549 | 0.93 | ALDH1A1 (0.57) | PDE5AALDH1A1PDE6DPDE6APDE6G | |
| SCHEMBL19158549 | 0.93 | PDE5A (0.57) | PDE5AALDH1A1PDE6DPDE6APDE6G | |
| SCHEMBL16137867 | 0.90 | ALDH1A1 (0.60) | PDE5AALDH1A1SYKMAPK1HTT | |
| SCHEMBL16815900 | 0.89 | ALDH1A1 (0.58) | PDE5AALDH1A1PDE6DPDE6APDE6G | |
| SCHEMBL4976195 | 0.88 | PDE5A (0.62) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16345647 | 0.88 | PDE5A (0.62) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4974720 | 0.88 | PDE5A (0.54) | PDE5APDE10A | |
| SCHEMBL31189121 | 0.88 | PDE5A (0.54) | PDE5APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117430591-A | Synthesis method of avanafil | 康普药业股份有限公司 | 2024-01-23 | — | — | CN | claimed |
| CN-115304585-A | Preparation method of avanafil | 江苏恒沛药物科技有限公司 | 2022-11-08 | — | — | CN | claimed |
| CN-117430591-A | Synthesis method of avanafil | 康普药业股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-115304585-A | Preparation method of avanafil | 江苏恒沛药物科技有限公司 | 2022-11-08 | — | — | CN | disclosed |