Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23578845 | 1.00 | DHODH (0.55) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL26074850 | 0.92 | PLA2G2A (0.61) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL29972871 | 0.90 | RXFP1 (0.53) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23578798 | 0.90 | RXFP1 (0.53) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL29617652 | 0.88 | DHODH (0.71) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23576327 | 0.88 | DHODH (0.71) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23578864 | 0.87 | DHODH (0.58) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL29973103 | 0.87 | DHODH (0.58) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23578598 | 0.84 | DHODH (0.58) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL23590128 | 0.84 | DHODH (0.58) | DHODHKDM4ESMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081520-A1 | COMPOSITIONS FOR USE IN THE INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | Ohio State Innovation Foundation (US) | 2022-11-02 | — | — | EP | disclosed |