SCHEMBL29974335

SCHEMBL29974335

O=C(O)C1(CCCCl)CC(F)CN1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ARG2 P78540 20/20 0.49
ARG1 P05089 19/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29930292 1.00 ARG2 (0.49) ARG2ARG1
SCHEMBL22208186 1.00 ARG2 (0.49) ARG2ARG1
SCHEMBL29851014 0.90 ARG2 (0.44) ARG2ARG1
SCHEMBL27003466 0.84 ARG2 (0.49) ARG2ARG1
SCHEMBL27003399 0.84 ARG2 (0.49) ARG2ARG1
SCHEMBL24651733 0.83 ARG2 (0.36) ARG2ARG1
SCHEMBL24543292 0.83 ARG2 (0.36) ARG2ARG1
Hydrochloric Acid SCHEMBL27003435 0.83 ARG2 (0.48) ARG2ARG1
Hydrochloric Acid SCHEMBL27003460 0.83 ARG2 (0.48) ARG2ARG1
Hydrochloric Acid SCHEMBL30565848 0.82 ARG2 (0.36) ARG2ARG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4329757-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE Amgen Inc. (US) 2024-03-06 EP disclosed
EP-4329888-A1 2-AMINOBENZOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF Amgen Inc. (US) 2024-03-06 EP disclosed
WO-2022232332-A1 2-AMINOBENZOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF AMGEN INC. (US) 2022-11-03 WO disclosed
WO-2022232331-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2022-11-03 WO disclosed