ARG2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL894218	0.88	20/20
SCHEMBL894219	0.88	20/20
SCHEMBL894204	0.71	20/20
SCHEMBL893861	1.00	19/20
SCHEMBL893860	0.77	19/20
SCHEMBL894054	0.67	19/20
SCHEMBL893976	0.66	19/20
SCHEMBL894216	0.65	19/20
SCHEMBL894122	0.64	19/20
SCHEMBL893767	0.63	19/20
Hydrochloric Acid (SCHEMBL894017)	0.62	19/20
Hydrochloric Acid (SCHEMBL894036)	0.57	19/20
SCHEMBL894041	1.00	18/20
Hydrochloric Acid (SCHEMBL894097)	0.98	18/20
SCHEMBL894098	0.89	18/20
SCHEMBL894099	0.89	18/20
SCHEMBL894055	0.76	18/20
SCHEMBL893946	0.69	18/20
SCHEMBL893947	0.69	18/20
SCHEMBL894175	0.65	18/20

Clinical trials — most relevant to ARG2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-Arginine Role for Stone Lower Ureter : A Randomized Control Study	PHASE4	COMPLETED
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial	PHASE3	COMPLETED
L-arginine and Brown Adipose Tissue	PHASE3	UNKNOWN
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19	PHASE2	COMPLETED
Nitrite Supplementation in Long COVID Patients	PHASE2	COMPLETED
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial	PHASE2	COMPLETED
EF-M2 (Immutalon) Multiple Ascending Dose Study in Moderate-to-Severe Rheumatoid Arthritis	PHASE1/PHASE2	COMPLETED
L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome	PHASE2	COMPLETED
Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma	PHASE2	COMPLETED
Arginase Inhibition and Microvascular Endothelial Function in Type 2 Diabetes	PHASE1/PHASE2	COMPLETED
Effect of Metformin and Combination of Olive Oil Plus Nutritional Supplements on Inflammatory Markers IL-6 and IL-8 in PCOS.	PHASE2	COMPLETED
Arginase-1 Peptide Vaccine in Patients With Metastatic Solid Tumors	PHASE1	COMPLETED
The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction	PHASE1	COMPLETED
Arginase Inhibition in Humans With Obesity	EARLY_PHASE1	COMPLETED
Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling	nan	NOT_YET_RECRUITING
Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes	nan	UNKNOWN
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Relation of White Blood Cell Function to Diabetes	nan	COMPLETED
Effects of Citrulline on Gut Functioning During Excercise	nan	UNKNOWN
Nitrate Supplementation and Exercise Tolerance in Patients With Type 2 Diabetes	nan	COMPLETED
Glucagon Like Peptide-1 in Remote Ischemic Conditioning	nan	COMPLETED
Preterm Arginine INTake Study	nan	COMPLETED
Effect Inhaled Nitric Oxide in Adult Liver Transplant	nan	NOT_YET_RECRUITING
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.	nan	NOT_YET_RECRUITING
Mitochondrial Function of Immune Cells in Sepsis	nan	COMPLETED
Mitochondrial Impairment in Muscle Insulin Resistance	nan	COMPLETED
L-Arginine in the Treatment of Peripheral Arterial Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ARG2 binder may also engage these)

Protein	Name	Similarity
O08701	—	1.000	O08701 →
O08691	—	1.000	O08691 →
Q58DL1	—	1.000	Q58DL1 →
Q91554	—	1.000	Q91554 →
Q91553	—	0.999	Q91553 →
Q4VK78	—	0.998	Q4VK78 →
P49900	—	0.998	P49900 →
Q91555	—	0.996	Q91555 →
Q95JC8	—	0.994	Q95JC8 →
ARG1	Arginase-1	0.994	landscape →
Q61176	—	0.993	Q61176 →
Q2KJ64	—	0.993	Q2KJ64 →
P30759	—	0.992	P30759 →
P07824	—	0.992	P07824 →
A0A2R2JFW7	—	0.990	A0A2R2JFW7 →
Q95KM0	—	0.990	Q95KM0 →
P37818	—	0.989	P37818 →
P00812	—	0.988	P00812 →
Q10066	—	0.988	Q10066 →
Q90XD2	—	0.984	Q90XD2 →
Q9BSE5	—	0.984	Q9BSE5 →
Q8TB37	—	0.983	Q8TB37 →
Q12611	—	0.983	Q12611 →
Q6CLS8	—	0.982	Q6CLS8 →
Q8AWD2	—	0.980	Q8AWD2 →
Q99KE1	—	0.980	Q99KE1 →
Q6NUA1	—	0.980	Q6NUA1 →
Q0D2L3	—	0.980	Q0D2L3 →
Q16P90	—	0.980	Q16P90 →
Q9GZT8	—	0.980	Q9GZT8 →