Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.87 |
| ▸ | PLK1 | P53350 | 2/20 | 0.85 |
| ▸ | GAK | O14976 | 1/20 | 0.85 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.85 |
| ▸ | JAK2 | O60674 | 1/20 | 0.85 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.85 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.85 |
| ▸ | PAK4 | O96013 | 1/20 | 0.85 |
| ▸ | ABL1 | P00519 | 1/20 | 0.85 |
| ▸ | LCK | P06239 | 1/20 | 0.85 |
| ▸ | FYN | P06241 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.85 |
| ▸ | BCR | P11274 | 1/20 | 0.85 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.85 |
| ▸ | SYK | P43405 | 1/20 | 0.85 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.85 |
| ▸ | NEK2 | P51955 | 1/20 | 0.85 |
| ▸ | NEK3 | P51956 | 1/20 | 0.85 |
| ▸ | JAK3 | P52333 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1816265 | 1.00 | WEE1 (0.87) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL25585760 | 0.93 | WEE1 (0.79) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL23100040 | 0.93 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL18797921 | 0.93 | WEE1 (0.87) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL30305667 | 0.92 | WEE1 (0.86) | WEE1PLK1GAKEPHB6JAK2 | |
| Adavosertib SCHEMBL29381006 | 0.92 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| Adavosertib SCHEMBL30559444 | 0.92 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| Adavosertib SCHEMBL1504444 | 0.92 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL18797915 | 0.92 | WEE1 (0.86) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL25826222 | 0.92 | WEE1 (0.79) | WEE1PLK1GAKEPHB6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4416151-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | Padarn Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| EP-4329815-A1 | DEUBIQUITINASE-TARGETING CHIMERAS AND RELATED METHODS | Novartis AG (CH) | 2024-03-06 | — | — | EP | disclosed |
| WO-2023064164-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | PADARN THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2022251224-A1 | WEE1 INHIBITORS AND METHODS FOR TREATING CANCER | RECURIUM IP HOLDINGS, LLC (US) | 2022-12-01 | — | — | WO | disclosed |
| WO-2022232634-A1 | DEUBIQUITINASE-TARGETING CHIMERAS AND RELATED METHODS | NOVARTIS AG (CH) | 2022-11-03 | — | — | WO | disclosed |