Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.87 |
| ▸ | PLK1 | P53350 | 2/20 | 0.85 |
| ▸ | GAK | O14976 | 1/20 | 0.85 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.85 |
| ▸ | JAK2 | O60674 | 1/20 | 0.85 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.85 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.85 |
| ▸ | PAK4 | O96013 | 1/20 | 0.85 |
| ▸ | ABL1 | P00519 | 1/20 | 0.85 |
| ▸ | LCK | P06239 | 1/20 | 0.85 |
| ▸ | FYN | P06241 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.85 |
| ▸ | BCR | P11274 | 1/20 | 0.85 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.85 |
| ▸ | SYK | P43405 | 1/20 | 0.85 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.85 |
| ▸ | NEK2 | P51955 | 1/20 | 0.85 |
| ▸ | NEK3 | P51956 | 1/20 | 0.85 |
| ▸ | JAK3 | P52333 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29975700 | 1.00 | WEE1 (0.87) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL25585760 | 0.93 | WEE1 (0.79) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL23100040 | 0.93 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL18797921 | 0.93 | WEE1 (0.87) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL30305667 | 0.92 | WEE1 (0.86) | WEE1PLK1GAKEPHB6JAK2 | |
| Adavosertib SCHEMBL29381006 | 0.92 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| Adavosertib SCHEMBL30559444 | 0.92 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| Adavosertib SCHEMBL1504444 | 0.92 | WEE1 (1.00) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL18797915 | 0.92 | WEE1 (0.86) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL25826222 | 0.92 | WEE1 (0.79) | WEE1PLK1GAKEPHB6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270212-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | PADARN THERAPEUTICS INC (US) | 2025-08-28 | — | — | US | disclosed |
| US-20240252655-A1 | DEUBIQUITINASE-TARGETING CHIMERAS AND RELATED METHODS | NOVARTIS AG (CH) | 2024-08-01 | — | — | US | disclosed |
| EP-4329815-A1 | DEUBIQUITINASE-TARGETING CHIMERAS AND RELATED METHODS | Novartis AG (CH) | 2024-03-06 | — | — | EP | disclosed |
| WO-2023125944-A1 | COMPOUND CONTAINING HETEROCYCLIC RING | 正大天晴药业集团股份有限公司 | 2023-07-06 | — | — | WO | disclosed |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| WO-2023083194-A1 | WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF | 杭州格博生物医药有限公司 | 2023-05-19 | — | — | WO | disclosed |
| WO-2023064164-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | PADARN THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2023064164-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | PADARN THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| EP-4122925-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | Medshine Discovery Inc. (CN) | 2023-01-25 | — | — | EP | disclosed |
| US-7834019-B2 | Substituted pyrazolo[3,4-d]pyrimidinone derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-7834019-B2 | Substituted pyrazolo[3,4-d]pyrimidinone derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-20100063024-A1 | Dihydropyrazolopyrimidinone Derivatives | MERCK SHARP & DOHME LLC | 2010-03-11 | — | — | US | disclosed |
| US-20100063024-A1 | Dihydropyrazolopyrimidinone Derivatives | MERCK SHARP & DOHME LLC | 2010-03-11 | — | — | US | disclosed |
| US-20100063024-A1 | Dihydropyrazolopyrimidinone Derivatives | MERCK SHARP & DOHME LLC | 2010-03-11 | — | — | US | disclosed |
| EP-2017278-A1 | DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-01-21 | — | — | EP | disclosed |
| EP-2017278-A1 | DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-20070254892-A1 | Dihydropyrazolopyrimidinone derivatives | MSD K.K. (JP) | 2007-11-01 | — | — | US | disclosed |
| US-20070254892-A1 | Dihydropyrazolopyrimidinone derivatives | MSD K.K. (JP) | 2007-11-01 | — | — | US | disclosed |
| US-20070254892-A1 | Dihydropyrazolopyrimidinone derivatives | MSD K.K. (JP) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240252655-A1 | DEUBIQUITINASE-TARGETING CHIMERAS AND RELATED METHODS | USP2, USP1, USP28 | WEE1 1990/4885PLK1 376/4885GAK 1917/4885 |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | PSMA6, PSMC1, PSMA1 | WEE1 3948/4885PLK1 2279/4885GAK 3761/4885 |
| US-20100063024-A1 | Dihydropyrazolopyrimidinone Derivatives | WEE1, WEE2, GRK3 | WEE1 1/4885PLK1 749/4885GAK 15/4885 |
| US-20070254892-A1 | Dihydropyrazolopyrimidinone derivatives | WEE1, WEE2, GRK3 | WEE1 1/4885PLK1 749/4885GAK 15/4885 |
| US-20250270212-A1 | CHIMERIC COMPOUNDS USEFUL IN TREATING DISEASES | WEE1, WEE2, PARP1 | WEE1 1/4885PLK1 924/4885GAK 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.