SCHEMBL29976277

SCHEMBL29976277

COc1ccc(Cn2cc(-c3cc(C)nc(S(=O)(=O)CCC(OCc4ccccc4)c4ccccc4)n3)ccc2=O)cc1OC

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SDHB P21912 19/20 0.58
PDE4A P27815 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4C Q08493 1/20 0.37
PDE4D Q08499 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19805741 1.00 SDHB (0.58) SDHBPDE4APDE4BPDE4CPDE4D
SCHEMBL20985722 0.91 SDHB (0.73) SDHB
SCHEMBL20985617 0.91 SDHB (0.58) SDHB
SCHEMBL20985689 0.91 SDHB (0.58) SDHB
SCHEMBL20985639 0.89 SDHB (0.57) SDHB
SCHEMBL29976455 0.89 SDHB (0.57) SDHB
SCHEMBL20985627 0.89 SDHB (0.54) SDHB
SCHEMBL29976626 0.87 SDHB (0.51) SDHBPDE4APDE4BPDE4CPDE4D
SCHEMBL20985638 0.87 SDHB (0.51) SDHBPDE4APDE4BPDE4CPDE4D
SCHEMBL29975980 0.84 SDHB (0.45) SDHBPDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110023292-B Apoptosis inhibitors 北京生命科学研究所 2022-10-04 CN disclosed