SCHEMBL29976830

SCHEMBL29976830

[2H]c1ncnc2ccncc12

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EGFR P00533 11/20 0.47
PIK3CD O00329 1/20 0.35
PIK3CA P42336 1/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HTT P42858 1/20 0.34
NCOA1 Q15788 1/20 0.34
NCOA3 Q9Y6Q9 1/20 0.34
CSNK1D P48730 1/20 0.33
CSNK1E P49674 1/20 0.33
CLK1 P49759 1/20 0.33
DYRK1A Q13627 1/20 0.33
HSP90AA1 P07900 1/20 0.32
MKNK2 Q9HBH9 1/20 0.32
PDGFRB P09619 1/20 0.32
PDGFRA P16234 1/20 0.32
METAP2 P50579 1/20 0.31
METAP1 P53582 1/20 0.31
CYP2A6 P11509 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL137377 0.82 EGFR (0.60) EGFRPIK3CDPIK3CAKDM4EALDH1A1
SCHEMBL29409337 0.82 EGFR (0.60) EGFRPIK3CDPIK3CAKDM4EALDH1A1
Hydrochloric Acid SCHEMBL31066682 0.80 EGFR (0.58) EGFRPIK3CDPIK3CAKDM4EALDH1A1
Hydrochloric Acid SCHEMBL322987 0.80 EGFR (0.58) EGFRPIK3CDPIK3CAKDM4EALDH1A1
Quinazoline SCHEMBL29937288 0.74 EGFR (0.61) EGFRPIK3CDPIK3CAKDM4EALDH1A1
SCHEMBL88606 0.71 EGFR (0.58) EGFRPIK3CDPIK3CAKDM4EALDH1A1
SCHEMBL29409356 0.71 EGFR (0.58) EGFRPIK3CDPIK3CAKDM4EALDH1A1
SCHEMBL38663711 0.70 CYP19A1 (0.37) KDM4EHTTCSNK1DCSNK1ECLK1
Hydrochloric Acid SCHEMBL30749407 0.70 EGFR (0.56) EGFRPIK3CDPIK3CAKDM4EALDH1A1
Hydrochloric Acid SCHEMBL30749417 0.70 EGFR (0.56) EGFRPIK3CDPIK3CAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023134465-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF 上海艾力斯医药科技股份有限公司 2023-07-20 WO disclosed
WO-2023056951-A1 ARYL-SUBSTITUTED HETEROCYCLIC COMPOUND 杭州德睿智药科技有限公司 2023-04-13 WO disclosed
WO-2023001123-A1 NEW PYRIDOPYRIMIDINE DERIVATIVE 上海艾力斯医药科技股份有限公司 2023-01-26 WO disclosed
WO-2023274324-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF, AND APPLICATION THEREOF 上海艾力斯医药科技股份有限公司 2023-01-05 WO disclosed
WO-2022228568-A1 PYRIDINO- OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 劲方医药科技(上海)有限公司 2022-11-03 WO disclosed