Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | IGF1R | P08069 | 5/20 | 0.37 |
| ▸ | INSR | P06213 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179110 | 1.00 | ALK (0.42) | ALKZAP70MEN1KMT2AEGFR | |
| SCHEMBL23154083 | 0.89 | ZAP70 (0.40) | ALKZAP70MEN1KMT2AEGFR | |
| SCHEMBL17411151 | 0.88 | ALK (0.51) | ALKEGFRIGF1RINSRPTK2 | |
| SCHEMBL24179135 | 0.88 | MEN1 (0.43) | ALKMEN1KMT2AEGFRIGF1R | |
| SCHEMBL23153751 | 0.87 | EGFR (0.38) | ALKZAP70MEN1KMT2AEGFR | |
| SCHEMBL29877067 | 0.87 | NPC1 (0.42) | ALKMEN1KMT2AEGFRIGF1R | |
| SCHEMBL24179106 | 0.87 | NPC1 (0.42) | ALKMEN1KMT2AEGFRIGF1R | |
| SCHEMBL30776709 | 0.86 | MEN1 (0.41) | ALKMEN1KMT2AEGFRIGF1R | |
| SCHEMBL23153957 | 0.84 | EGFR (0.40) | ALKZAP70MEN1KMT2AEGFR | |
| SCHEMBL24179409 | 0.84 | MEN1 (0.40) | ALKMEN1KMT2AEGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024217481-A1 | EGFR DEGRADING AGENT, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2024-10-24 | — | — | WO | disclosed |
| CN-117425646-A | Phosphono derivative, composition thereof and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-01-19 | — | — | CN | disclosed |
| WO-2022228547-A1 | PHOSPHONYL DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL APPLICATION THEREOF | 四川海思科制药有限公司 | 2022-11-03 | — | — | WO | disclosed |