Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23154199 | 0.91 | EGFR (0.39) | EGFRMEN1KMT2AALKIGF1R | |
| SCHEMBL23153748 | 0.89 | EGFR (0.41) | EGFRMEN1KMT2AALKIGF1R | |
| SCHEMBL23154147 | 0.88 | INSR (0.38) | EGFRMEN1KMT2AZAP70ALK | |
| SCHEMBL23154332 | 0.88 | EGFR (0.37) | EGFRMEN1KMT2AALKIGF1R | |
| SCHEMBL23154217 | 0.88 | MEN1 (0.40) | EGFRMEN1KMT2AALKIGF1R | |
| SCHEMBL24179110 | 0.87 | ALK (0.42) | EGFRMEN1KMT2AZAP70ALK | |
| SCHEMBL29977264 | 0.87 | ALK (0.42) | EGFRMEN1KMT2AZAP70ALK | |
| SCHEMBL23153980 | 0.86 | MEN1 (0.39) | EGFRMEN1KMT2AALKIGF1R | |
| SCHEMBL23154083 | 0.85 | ZAP70 (0.40) | EGFRMEN1KMT2AZAP70ALK | |
| SCHEMBL23153875 | 0.84 | EGFR (0.42) | EGFRMEN1KMT2AZAP70ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021057882-A1 | EGFR INHIBITOR, COMPOSITION AND PREPARATION METHOD THEREFOR | 贝达药业股份有限公司 | 2021-04-01 | — | — | WO | disclosed |