SCHEMBL29977301

SCHEMBL29977301

CC(C)[Si](C#Cc1cccc2ccccc12)(C(C)C)C(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.45
CHAT P28329 1/20 0.45
ACACB O00763 1/20 0.40
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
ALDH1A1 P00352 3/20 0.36
CYP2A6 P11509 2/20 0.36
CACNA2D1 P54289 1/20 0.36
CACNB2 Q08289 1/20 0.36
CACNA1C Q13936 1/20 0.36
HPRT1 P00492 1/20 0.35
MEN1 O00255 1/20 0.35
MITF O75030 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
RAD52 P43351 1/20 0.35
KMT2A Q03164 1/20 0.35
HRH3 Q9Y5N1 4/20 0.35
CYP1A2 P05177 2/20 0.35
CYP1A1 P04798 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12405326 0.87 CACNA2D1 (0.35) GRM5CHATCACNA2D1CACNB2CACNA1C
SCHEMBL28433044 0.83 GRM5 (0.33) GRM5CHATALDH1A1CACNA2D1CACNB2
SCHEMBL30259973 0.82 CYP1A2 (0.35) GRM5CHATCYP2A6CYP1A2
SCHEMBL31491217 0.82 PLAU (0.44) GRM5CHATALDH1A1MAPTHTT
SCHEMBL25410554 0.82 ESR1 (0.38) GRM5CACNA2D1CACNB2CACNA1CMEN1
SCHEMBL4586339 0.82 CACNA2D1 (0.36) ALDH1A1CACNA2D1CACNB2CACNA1CCYP1A2
Hydrochloric Acid SCHEMBL30157118 0.81 ESR1 (0.38) GRM5CACNA2D1CACNB2CACNA1CCYP1A2
SCHEMBL5012545 0.79 GRM5 (0.49) GRM5CHATACACBCA1CA2
SCHEMBL20044978 0.79 HSD17B10 (0.38) ALDH1A1CYP2A6CACNA2D1CACNB2CACNA1C
SCHEMBL5610827 0.79 GRM5 (0.30) GRM5CACNA2D1CACNB2CACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024178304-A1 KRAS MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2024-08-29 WO disclosed
CN-117677624-A Novel pyridopyrimidine derivatives 上海艾力斯医药科技股份有限公司 2024-03-08 CN disclosed
WO-2024012519-A1 PAN-KRAS INHIBITOR 北京华森英诺生物科技有限公司 2024-01-18 WO disclosed
WO-2023098425-A1 KRAS INHIBITORS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF 上海和誉生物医药科技有限公司 2023-06-08 WO disclosed
WO-2022228568-A1 PYRIDINO- OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 劲方医药科技(上海)有限公司 2022-11-03 WO disclosed