SCHEMBL5012545

SCHEMBL5012545

C[Si](C)(C)C#Cc1cccc2ccccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.49
CHAT P28329 1/20 0.49
ALDH1A1 P00352 5/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
TSHR P16473 3/20 0.41
HSD17B10 Q99714 3/20 0.41
CYP1A2 P05177 3/20 0.41
KDM4E B2RXH2 2/20 0.41
MAPT P10636 2/20 0.41
CYP3A4 P08684 2/20 0.41
HPGD P15428 2/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
CYP2A6 P11509 4/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
POLB P06746 1/20 0.38
MITF O75030 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12144561 0.85 ALOX15 (0.40) GRM5CHATALDH1A1MEN1KMT2A
SCHEMBL12405322 0.83 KDM4E (0.39) GRM5CHATALDH1A1MEN1KMT2A
SCHEMBL9472950 0.83 ALDH1A1 (0.38) GRM5CHATALDH1A1MEN1KMT2A
SCHEMBL30620185 0.83 CYP1A2 (0.41) GRM5CHATALDH1A1MEN1KMT2A
SCHEMBL20534467 0.83 CYP1A2 (0.41) GRM5CHATALDH1A1MEN1KMT2A
SCHEMBL1777875 0.82 ENPP3 (0.42) ALDH1A1MEN1KMT2ATSHRHSD17B10
SCHEMBL2776015 0.80 CHAT (0.60) GRM5CHATALDH1A1MEN1KMT2A
SCHEMBL3839029 0.80 KDM4E (0.49) GRM5ALDH1A1MEN1KMT2ATSHR
SCHEMBL29661843 0.80 CHAT (0.60) GRM5CHATALDH1A1MEN1KMT2A
SCHEMBL18081447 0.80 ELANE (0.40) GRM5CHATALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US claimed
US-20220056167-A1 Functionalized Cyclic Polymers and Methods of Preparing Same NATIONAL SCIENCE FOUNDATION 2022-02-24 US claimed
WO-2020223672-A1 FUNCTIONALIZED CYCLIC POLYMERS AND METHODS OF PREPARING SAME UNIVERSITY OF FLORIDA RESEARCHFOUNDATION, INC. (US) 2020-11-05 WO claimed
WO-2025226827-A1 LIVER RECEPTOR HOMOLOG-1 (LRH-1) ANTAGONISTS AND USES THEREOF EMORY UNIVERSITY (US) 2025-10-30 WO disclosed
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US disclosed
CN-117003917-A Phenylene Polymer, method and use thereof 西蒙弗雷泽大学 2023-11-07 CN disclosed
CN-117003969-A Phenylene Polymer, method and use thereof 西蒙弗雷泽大学 2023-11-07 CN disclosed
US-20230287262-A1 PHOTON UPCONVERSION COMPOSITION, FILM, METHOD FOR CONVERTING VISIBLE LIGHT INTO ULTRAVIOLET LIGHT, AND COMPOUND KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2023-09-14 US disclosed
US-20230051031-A1 MULTI-FUNCTIONAL HYBRID MATERIAL BASED ON SEPIOLITE FOR ENVIRONMENTAL RECOVERY AND BIO-REMEDIATION CONSIGLIO NAZIONALE DELLE RICERCHE (IT) 2023-02-16 US disclosed
US-20230034883-A1 MULTI-FUNCTIONAL HYBRID MATERIAL BASED ON NATURAL CLAYS FOR ENVIRONMENTAL RECOVERY AND BIO-REMEDIATION CONSIGLIO NAZIONALE DELLE RICERCHE (60%) (IT) 2023-02-02 US disclosed
EP-4076730-A1 MULTI-FUNCTIONAL HYBRID MATERIAL BASED ON SEPIOLITE FOR ENVIRONMENTAL RECOVERY AND BIO-REMEDIATION Consiglio Nazionale Delle Ricerche (IT) 2022-10-26 EP disclosed
US-20150361111-A1 Catalytic method for obtaining substituted (triorganosilyl)alkynes and their derivatives UNIV ADAM MICKIEWICZ (PL) 2015-12-17 US disclosed
US-9108994-B2 (Triorganosilyl)alkynes and their derivatives and a new catalytic method for obtaining new and conventional substituted (triorganosilyl)alkynes and their derivatives ADAM MICKIEWICZ UNIVERSITY (PL) 2015-08-18 US disclosed
US-20140005427-A1 NEW (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES AND A NEW CATALYTIC METHOD FOR OBTAINING NEW AND CONVENTIONAL SUBSTITUTED (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES ADAM MICKIEWICZ UNIVERSITY (PL) 2014-01-02 US disclosed
EP-2658861-A2 NEW (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES AND A NEW CATALYTIC METHOD FOR OBTAINING NEW AND CONVENTIONAL SUBSTITUTED (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES Adam Mickiewicz University (PL) 2013-11-06 EP disclosed
CN-103328489-A New (triorganosilyl)alkynes and their derivatives and a new catalytic method for obtaining new and conventional substituted (triorganosilyl)alkynes and their derivatives UNIV ADAM MICKIEWICZ 2013-09-25 CN disclosed
CN-102883718-A Analogues for the treatment or prevention of flavivirus infections VERTEX PHARMA 2013-01-16 CN disclosed
WO-2012091588-A2 NEW (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES AND A NEW CATALYTIC METHOD FOR OBTAINING NEW AND CONVENTIONAL SUBSTITUTED (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES ADAM MICKIEWICZ UNIVERSITY (PL) 2012-07-05 WO disclosed
EP-1389626-B1 Aromatic copolymers of pyrroles and an electroluminescent element using the same KOREA INST SCI & TECH (KR) 2008-12-31 EP disclosed
EP-1389626-A1 Aromatic copolymers of pyrroles and an electroluminescent element using the same Korea Institute of Science and Technology (KR) 2004-02-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140005427-A1 NEW (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES AND A NEW CATALYTIC METHOD FOR OBTAINING NEW AND CONVENTIONAL SUBSTITUTED (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES TPI1, ALK, INO80C GRM5 1794/4885CHAT 845/4885ALDH1A1 325/4885
US-20150361111-A1 Catalytic method for obtaining substituted (triorganosilyl)alkynes and their derivatives TST, AS3MT, DCXR GRM5 2545/4885CHAT 560/4885ALDH1A1 1165/4885
US-20230287262-A1 PHOTON UPCONVERSION COMPOSITION, FILM, METHOD FOR CONVERTING VISIBLE LIGHT INTO ULTRAVIOLET LIGHT, AND COMPOUND NUDC, CCNL2, SPIN3 GRM5 4516/4885CHAT 1374/4885ALDH1A1 2125/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.