Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779590 | 0.86 | SLC18A3 (0.42) | SLC18A3MEN1KMT2AHTTMGLL | |
| SCHEMBL2241229 | 0.86 | SLC18A3 (0.55) | SLC18A3HTTKDM1AMAOANPC1 | |
| SCHEMBL2241225 | 0.86 | SLC18A3 (0.55) | SLC18A3HTTKDM1AMAOANPC1 | |
| SCHEMBL6042250 | 0.86 | SLC18A3 (0.55) | SLC18A3HTTKDM1AMAOANPC1 | |
| SCHEMBL23291451 | 0.85 | KDM1A (0.45) | SLC18A3MEN1KMT2AHTTKDM1A | |
| SCHEMBL22804711 | 0.85 | KDM1A (0.45) | SLC18A3MEN1KMT2AHTTKDM1A | |
| SCHEMBL6042361 | 0.85 | NPC1 (0.48) | SLC18A3MEN1KMT2AHTTKDM1A | |
| SCHEMBL6041675 | 0.85 | KDM1A (0.45) | SLC18A3MEN1KMT2AHTTKDM1A | |
| SCHEMBL6043859 | 0.85 | MAPT (0.45) | NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL6041432 | 0.85 | RAB9A (0.45) | SLC18A3MEN1KMT2AHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333899-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022235945-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2022-11-10 | — | — | WO | disclosed |