Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24703836 | 1.00 | PRMT5 (0.42) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL18179491 | 0.94 | PRMT5 (0.43) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL31704275 | 0.88 | PRMT5 (0.44) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL28832392 | 0.88 | PRMT5 (0.44) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL8279277 | 0.87 | PRMT5 (0.42) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL29279177 | 0.86 | PRMT5 (0.42) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL16809699 | 0.85 | PRMT5 (0.42) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL20683041 | 0.84 | PRMT5 (0.42) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL18195440 | 0.84 | PRMT5 (0.42) | PRMT5WDR77AAK1USP30BACE1 | |
| SCHEMBL12501628 | 0.82 | PRMT5 (0.43) | PRMT5WDR77AAK1USP30BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333899-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022235945-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2022-11-10 | — | — | WO | disclosed |