SCHEMBL29977830

SCHEMBL29977830

O=C(c1ccc(OC(F)(F)F)cc1)N1CCc2cc(-c3noc(C(F)(F)F)n3)sc2C1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 9/20 0.47
HDAC6 Q9UBN7 2/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
PDE4B Q07343 1/20 0.43
PDE4D Q08499 1/20 0.43
ABCB1 P08183 1/20 0.39
EPHX2 P34913 2/20 0.39
MGLL Q99685 1/20 0.39
S1PR1 P21453 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
PRLHR P49683 2/20 0.38
STAT3 P40763 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29978179 0.91 HDAC4 (0.49) HDAC4HDAC6HDAC2HDAC8PDE4B
SCHEMBL29978476 0.89 HDAC4 (0.50) HDAC4HDAC6HDAC2HDAC8MGLL
SCHEMBL29978604 0.89 HDAC4 (0.50) HDAC4HDAC6HDAC2HDAC8MGLL
SCHEMBL29978418 0.88 HDAC4 (0.52) HDAC4HDAC6HDAC2HDAC8MGLL
SCHEMBL29978134 0.88 EPHX2 (0.45) EPHX2
SCHEMBL29978213 0.88 HDAC4 (0.50) HDAC4HDAC6HDAC2HDAC8MGLL
SCHEMBL29978650 0.88 HDAC4 (0.48) HDAC4HDAC6HDAC2HDAC8MGLL
SCHEMBL29978646 0.88 HDAC4 (0.48) HDAC4HDAC6HDAC2HDAC8MGLL
SCHEMBL29978536 0.84 HDAC4 (0.49) HDAC4HDAC6HDAC2HDAC8PDE4B
SCHEMBL29977956 0.84 HDAC4 (0.42) HDAC4HDAC6HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO claimed
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO disclosed