SCHEMBL29978183

SCHEMBL29978183

COc1cccc(C(=O)N2CCc3sc(-c4noc(C(F)(F)F)n4)cc3C2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.47
ALDH1A1 P00352 4/20 0.45
GAA P10253 1/20 0.45
HPGD P15428 3/20 0.45
TSHR P16473 1/20 0.45
PDE4B Q07343 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HDAC4 P56524 4/20 0.43
HDAC6 Q9UBN7 2/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
CYP3A4 P08684 1/20 0.43
NAMPT P43490 1/20 0.41
ABL1 P00519 1/20 0.40
BCR P11274 1/20 0.40
NPC1 O15118 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29978536 0.91 HDAC4 (0.49) ALDH1A1HPGDTSHRPDE4BHDAC4
SCHEMBL29978176 0.89 GRM5 (0.45) GRM5HPGDHDAC4HDAC6HDAC2
SCHEMBL29977987 0.88 SMN1; SMN2 (0.50) GRM5ALDH1A1HPGDTSHRHDAC4
SCHEMBL29978514 0.88 GRM5 (0.46) GRM5PDE4BHDAC4HDAC6HDAC2
SCHEMBL29978387 0.88 HDAC4 (0.50) GRM5HDAC4HDAC6HDAC2HDAC8
SCHEMBL29978406 0.87 NPC1 (0.53) HDAC6HDAC8NAMPTNPC1RAB9A
SCHEMBL29978512 0.87 GAA (0.46) ALDH1A1GAAHPGDTSHRHDAC4
SCHEMBL29978344 0.86 HDAC4 (0.39) ALDH1A1HPGDTSHRHDAC4HDAC6
SCHEMBL29978368 0.84 HDAC4 (0.40) ALDH1A1HPGDTSHRHDAC4HDAC6
SCHEMBL29978909 0.84 HDAC4 (0.48) HDAC4HDAC6HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO claimed
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO disclosed