Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 1.00 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009808 | 1.00 | TGFBR1 (1.00) | TGFBR1TGFB2CYP2A6IRAK4MAPK14 | |
| SCHEMBL2010521 | 0.92 | TGFBR1 (1.00) | TGFBR1TGFB2MAPK14 | |
| SCHEMBL29977977 | 0.92 | TGFBR1 (1.00) | TGFBR1TGFB2MAPK14 | |
| SCHEMBL15445425 | 0.88 | TGFBR1 (0.78) | TGFBR1TGFB2RECQL | |
| SCHEMBL2009749 | 0.80 | TGFBR1 (1.00) | TGFBR1TGFB2CYP2A6IRAK4 | |
| SCHEMBL29978376 | 0.80 | TGFBR1 (1.00) | TGFBR1TGFB2CYP2A6IRAK4 | |
| SCHEMBL2007716 | 0.72 | TGFBR1 (1.00) | TGFBR1TGFB2CYP2A6MAPK14 | |
| SCHEMBL29978020 | 0.71 | TGFBR1 (1.00) | TGFBR1TGFB2IRAK4MAPK14 | |
| SCHEMBL2011347 | 0.71 | TGFBR1 (1.00) | TGFBR1TGFB2IRAK4MAPK14 | |
| SCHEMBL25942605 | 0.70 | TGFBR1 (0.55) | TGFBR1IRAK4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025090562-A1 | FORMULATIONS OF ALK-5 KINASE INHIBITORS AND USES THEREOF | THIRONA BIO, INC. (US) | 2025-05-01 | — | — | WO | disclosed |
| EP-4333853-A1 | METHODS FOR TREATING A PULMONARY DISEASE WITH AN ALK-5 (TGF BETA R1) INHIBITOR | Thirona Bio, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-117615765-A | Methods of treating pulmonary diseases with ALK-5 (TGF beta R1) inhibitors | 蒂罗纳生物股份有限公司 | 2024-02-27 | — | — | CN | disclosed |
| WO-2022235621-A1 | METHODS FOR TREATING A PULMONARY DISEASE WITH AN ALK-5 (TGF BETA R1) INHIBITOR | THIRONA BIO, INC. (US) | 2022-11-10 | — | — | WO | disclosed |