SCHEMBL29979080

SCHEMBL29979080

Cc1cccnc1-c1cccc(C(F)(F)F)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 5/20 0.58
CYP2A6 P11509 1/20 0.51
KCNA5 P22460 3/20 0.51
KCNH2 Q12809 1/20 0.51
EPHX2 P34913 1/20 0.49
TDO2 P48775 1/20 0.49
PIM1 P11309 1/20 0.46
KCNK3 O14649 1/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
GABRA1 P14867 1/20 0.45
HPGD P15428 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
GABRA2 P47869 1/20 0.45
HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10094689 1.00 TRPV1 (0.58) TRPV1CYP2A6KCNA5KCNH2EPHX2
SCHEMBL19248530 0.83 TRPV1 (0.49) TRPV1CYP2A6EPHX2
SCHEMBL16806015 0.82 TDO2 (0.50) KCNA5KCNH2TDO2PIM1KDM4E
SCHEMBL2861648 0.81 TRPV1 (0.68) TRPV1CYP2A6EPHX2KDM4EALDH1A1
SCHEMBL31606903 0.81 ADORA2A (0.51) KCNA5KCNH2TDO2PIM1NPY5R
SCHEMBL28581667 0.80 KCNA5 (0.60) TRPV1KCNA5KCNH2TDO2PIM1
SCHEMBL10094475 0.80 KCNA5 (0.60) TRPV1KCNA5KCNH2TDO2PIM1
Ammonia Solution, Strong SCHEMBL9046976 0.79 TDO2 (0.48) TRPV1KCNA5KCNH2TDO2KDM4E
SCHEMBL19248533 0.79 TRPV1 (0.63) TRPV1CYP2A6EPHX2CYP1A2
SCHEMBL1259738 0.78 CYP2A6 (0.56) TRPV1CYP2A6TDO2PIM1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115160354-A Method for efficiently synthesizing aryl silicon compound 南阳师范学院 2022-10-11 CN claimed
CN-115160354-A Method for efficiently synthesizing aryl silicon compound 南阳师范学院 2022-10-11 CN disclosed