Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23354124 | 1.00 | DHODH (0.47) | DHODHCYP3A4CYP2C8CYP2C9KDM4E | |
| SCHEMBL1927711 | 0.85 | FOLH1 (0.53) | DHODHALDH1A1MAPTRAB9ACES2 | |
| SCHEMBL7930737 | 0.83 | MEN1 (0.50) | DHODHNPC1RAB9AANO1CES2 | |
| SCHEMBL23354090 | 0.82 | ANO1 (0.57) | DHODHCYP3A4CYP2C8CYP2C9KDM4E | |
| SCHEMBL9754382 | 0.81 | CA1 (0.55) | DHODHCYP3A4CYP2C8CYP2C9KDM4E | |
| SCHEMBL23354270 | 0.80 | IL2 (0.49) | DHODHCYP2C8CES2CES1TTR | |
| SCHEMBL2553386 | 0.80 | DRD1 (0.43) | ALDH1A1CES2CES1TTRLTB4R | |
| SCHEMBL2558833 | 0.80 | MAPT (0.50) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4600246 | 0.79 | MEN1 (0.53) | CYP3A4CYP2C9KDM4ENPC1ALDH1A1 | |
| SCHEMBL25285914 | 0.76 | CA12 (0.61) | DHODHCYP3A4CYP2C8CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058448-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2022-09-21 | — | — | EP | disclosed |