Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 4/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16815290 | 1.00 | LPL (0.39) | LPLLIPGJAK2BTKESR1 | |
| SCHEMBL10269563 | 0.87 | LPL (0.42) | LPLLIPGJAK2BTKHIF1A | |
| SCHEMBL27611992 | 0.84 | JAK2 (0.35) | LPLLIPGJAK2BTKESR1 | |
| SCHEMBL31518231 | 0.82 | LPL (0.41) | LPLLIPGJAK2BTK | |
| SCHEMBL26814260 | 0.82 | LPL (0.41) | LPLLIPGJAK2BTK | |
| SCHEMBL16076557 | 0.82 | LPL (0.41) | LPLLIPGJAK2BTK | |
| SCHEMBL23057774 | 0.81 | LPL (0.40) | LPLLIPGJAK2BTKCA1 | |
| SCHEMBL29973574 | 0.81 | LPL (0.40) | LPLLIPGJAK2BTKCA1 | |
| SCHEMBL16815251 | 0.79 | JAK2 (0.35) | LPLLIPGJAK2BTKESR1 | |
| SCHEMBL26422891 | 0.79 | LPL (0.39) | LPLLIPGJAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022216945-A1 | MACROCYCLIC MCL1 INHIBITORS AND USES THEREOF | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-10-13 | — | — | WO | disclosed |