Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.73 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | HTR2B | P41595 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11192963 | 1.00 | TAAR1 (0.73) | TAAR1HTR2CHTR2BHTR2ADRD2 | |
| Azaquinzole SCHEMBL18863221 | 0.85 | TAAR1 (1.00) | TAAR1HTR2CHTR2BHTR2ACHRNA7 | |
| Azaquinzole SCHEMBL29387769 | 0.85 | TAAR1 (1.00) | TAAR1HTR2CHTR2BHTR2ACHRNA7 | |
| Azaquinzole SCHEMBL697061 | 0.85 | TAAR1 (1.00) | TAAR1HTR2CHTR2BHTR2ACHRNA7 | |
| SCHEMBL11385866 | 0.78 | TAAR1 (0.50) | TAAR1HTR2CHTR2BHTR2A | |
| SCHEMBL11377565 | 0.78 | DRD2 (0.52) | TAAR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL11375091 | 0.78 | TAAR1 (0.50) | TAAR1HTR2CHTR2BHTR2A | |
| SCHEMBL10671994 | 0.74 | TAAR1 (0.54) | TAAR1 | |
| SCHEMBL10704863 | 0.74 | TAAR1 (0.54) | TAAR1 | |
| SCHEMBL10704866 | 0.74 | TAAR1 (0.54) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4065586-A1 | 1,8-NAPHTHYRIDIN-2-ONE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2022-10-05 | — | — | EP | claimed |
| EP-4065586-A1 | 1,8-NAPHTHYRIDIN-2-ONE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2022-10-05 | — | — | EP | disclosed |