Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.70 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28881569 | 1.00 | BTK (0.70) | BTKCYP2C8KCNH2LTA4HKDM4E | |
| Hydrochloric Acid SCHEMBL16671009 | 0.99 | BTK (0.69) | BTKCYP2C8KCNH2LTA4HKDM4E | |
| SCHEMBL20998572 | 0.88 | BTK (0.72) | BTKCYP2C8KCNH2 | |
| SCHEMBL16597779 | 0.86 | BTK (0.71) | BTKLTA4HSCN9A | |
| SCHEMBL16670516 | 0.82 | BTK (1.00) | BTKCYP2C8KCNH2 | |
| SCHEMBL16676723 | 0.82 | BTK (0.48) | BTKLTA4HCYP3A4HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16670652 | 0.81 | BTK (0.48) | BTKLTA4HUSP2CYP1A2MAPK8 | |
| SCHEMBL28881829 | 0.81 | BTK (0.68) | BTKCYP2C8KCNH2 | |
| SCHEMBL16676769 | 0.81 | BTK (0.68) | BTKCYP2C8KCNH2 | |
| SCHEMBL29987334 | 0.81 | BTK (0.68) | BTKCYP2C8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304606-B | Degradation agent for simultaneously targeting BTK and GSPT proteins | 清华大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-115304606-A | Degradation agent for simultaneously targeting BTK and GSPT1 proteins | 清华大学 | 2022-11-08 | — | — | CN | disclosed |