Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667376 | 1.00 | GRM5 (0.40) | GRM5HRH3IKZF2AOC3NPC1 | |
| SCHEMBL24667440 | 0.89 | PRMT5 (0.42) | GRM5MCHR1PRMT5WDR77ADAM17 | |
| SCHEMBL30716909 | 0.89 | PRMT5 (0.42) | GRM5MCHR1PRMT5WDR77ADAM17 | |
| SCHEMBL29986704 | 0.88 | CSNK1A1 (0.39) | GRM5HRH3AOC3PIK3CGNR1H4 | |
| SCHEMBL24667377 | 0.88 | CSNK1A1 (0.39) | GRM5HRH3AOC3PIK3CGNR1H4 | |
| SCHEMBL24667583 | 0.86 | GRM5 (0.36) | GRM5HRH3IKZF2PIK3CGPDE10A | |
| SCHEMBL29986758 | 0.86 | GRM5 (0.36) | GRM5HRH3IKZF2PIK3CGPDE10A | |
| SCHEMBL24667401 | 0.86 | GRM5 (0.36) | GRM5HRH3IKZF2PIK3CGPDE10A | |
| SCHEMBL29987383 | 0.86 | GRM5 (0.36) | GRM5HRH3IKZF2PIK3CGPDE10A | |
| SCHEMBL24667307 | 0.85 | GRM5 (0.38) | GRM5HRH3NPC1RAB9AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320114-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117412960-A | Isoindolinone compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022216947-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2022-10-13 | — | — | WO | disclosed |