Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667378 | 1.00 | GRM5 (0.40) | GRM5SLC6A3MCHR1PDE10AHTR2C | |
| SCHEMBL24667398 | 0.86 | GRM5 (0.40) | GRM5SLC6A3MCHR1PDE10ACSNK1A1 | |
| SCHEMBL29987322 | 0.86 | GRM5 (0.40) | GRM5SLC6A3MCHR1PDE10ACSNK1A1 | |
| SCHEMBL29986550 | 0.85 | GRM5 (0.42) | GRM5SLC6A3MCHR1PDE10ACYP3A4 | |
| SCHEMBL24667346 | 0.85 | GRM5 (0.42) | GRM5SLC6A3MCHR1PDE10AHRH3 | |
| SCHEMBL29987375 | 0.85 | GRM5 (0.42) | GRM5SLC6A3MCHR1PDE10AHRH3 | |
| SCHEMBL24667400 | 0.85 | GRM5 (0.42) | GRM5SLC6A3MCHR1PDE10ACYP3A4 | |
| SCHEMBL24667307 | 0.84 | GRM5 (0.38) | GRM5MCHR1HTR2CCSNK1A1CSNK1D | |
| SCHEMBL29987867 | 0.84 | GRM5 (0.38) | GRM5MCHR1HTR2CCSNK1A1CSNK1D | |
| SCHEMBL24667390 | 0.84 | NPC1 (0.40) | GRM5HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320114-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117412960-A | Isoindolinone compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022216947-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2022-10-13 | — | — | WO | disclosed |