Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667307 | 1.00 | GRM5 (0.38) | GRM5HRH3CSNK1A1CSNK1DGSK3B | |
| SCHEMBL24667777 | 0.86 | GRM5 (0.39) | GRM5HRH3CSNK1A1CSNK1DGSK3B | |
| SCHEMBL29986601 | 0.86 | GRM5 (0.39) | GRM5HRH3CSNK1A1CSNK1DGSK3B | |
| SCHEMBL29987263 | 0.85 | GRM5 (0.40) | GRM5HRH3CSF1RNPC1RAB9A | |
| SCHEMBL24667376 | 0.85 | GRM5 (0.40) | GRM5HRH3CSF1RNPC1RAB9A | |
| SCHEMBL24667378 | 0.84 | GRM5 (0.40) | GRM5HRH3CSNK1A1CSNK1DGSK3B | |
| SCHEMBL29987385 | 0.84 | GRM5 (0.40) | GRM5HRH3CSNK1A1CSNK1DGSK3B | |
| SCHEMBL24667401 | 0.83 | GRM5 (0.36) | GRM5HRH3CSNK1A1CSNK1DGSK3B | |
| SCHEMBL24667583 | 0.83 | GRM5 (0.36) | GRM5HRH3CSNK1A1CSNK1DGSK3B | |
| SCHEMBL29986758 | 0.83 | GRM5 (0.36) | GRM5HRH3CSNK1A1CSNK1DGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320114-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117412960-A | Isoindolinone compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022216947-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2022-10-13 | — | — | WO | disclosed |