Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.64 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28881306 | 1.00 | SYK (0.64) | SYKBTKKCNH2ADRB1PRKD1 | |
| SCHEMBL28881308 | 0.83 | SYK (0.54) | SYK | |
| SCHEMBL28881298 | 0.83 | SYK (0.52) | SYKKCNH2 | |
| SCHEMBL29987508 | 0.83 | SYK (0.52) | SYKKCNH2 | |
| SCHEMBL736827 | 0.78 | SYK (1.00) | SYK | |
| SCHEMBL2693903 | 0.77 | SYK (0.73) | SYK | |
| SCHEMBL17009132 | 0.76 | SYK (0.53) | SYKADRB1PRKD1PRKD2 | |
| SCHEMBL737882 | 0.75 | SYK (1.00) | SYK | |
| SCHEMBL16782334 | 0.75 | SYK (0.85) | SYKKCNH2 | |
| SCHEMBL893995 | 0.75 | BTK (0.61) | SYKBTKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304606-A | Degradation agent for simultaneously targeting BTK and GSPT1 proteins | 清华大学 | 2022-11-08 | — | — | CN | disclosed |